Table 2.
Ref. | Sample | Labeling | Technique | Validation Method |
---|---|---|---|---|
[6] | PTT | CD | nanoLC-ESI-MS/MS | IHC |
[60] | PTT | CD | MALDI-TOF MS, nanoLC-ESI MS/MS | - |
[61] | PTT | Free | MALDI-TOF/TOF MS, MS/MS | IHC |
[62] | PTT | Free | MS/MS | WB |
[63] | PTT | Free | MS/MS | WB, IHC |
[64] | PTT | Free | LC-MS/MS | ELISA |
[65] | PTT | Free | LC-MS/MS | ELISA |
[66] | PTT | Free | MS/MS | - |
[67] | PTT | Free | LC-MS/MS | IHC |
[68] | PTT | Free | MALDI-TOF MS | ELISA |
[69] | PTT | Free | LC-MS/MS | IHC |
[70] | PTT | Free | MALDI-TOF MS | IHC, WB |
[71] | PTT | CD | MALDI-TOF/TOF-MS | WB, IHC |
[72] | PTT | Free | MALDI-TOF MS | WB |
[73] | PTT | Free | MALDI-TOF/TOF-MS | - |
[29] | PTT | Free | LC-MS/MS | IHC, WB |
[74] | PTT | Free | LC-MS/MS | - |
[75] | PTT | SI | LC-MS/MS | - |
[76] | PTT | Free | LC-MS/MS | IHC, WB |
[77] | PTT | LP | MS/MS | - |
[78] | PTT | Free | LC-MS(MS)2 | - |
[79] | PTT | Free | UHPLC/MS/MS2 | - |
[80] | Urine | CD | MALDI-TOF MS | IB |
[81] | Serum | Free | MALDI-QIT-TOF-MS | |
[82] | Serum | Free | (MRM) | WB |
[83] | Serum | Free | MS/MS | - |
[84] | Blood | Free | MALDI-MS | ELISA |
[85] | Serum | CD | MALDI-TOF/ TOF–MS | ELISA, WB |
[86] | Serum | IL | LC-MS / MS | - |
[87] | Urine | Free | LC/MS /MS | - |
[88] | Plasma | Free | LC−MS/MS | ELISA, WB, IHC, RT-qPCR |
[89] | Free | GeLC-MS/MS | - | |
[90] | Serum | Free | MALDI-TOF MS | PCR, WB, IHC |
[91] | PJ | Free | MALDI-TOF MS MS/MS | WB, IHC, ELISA |
[92] | Serum | Free | MALDI-TOF | WB |
Ref.: Reference; PDF: Pancreatic duct fluid, PJ: Pancreatic juice; PTT: Pancreatic tumor tissue; SI: Stable Isotopic; IL: Isobaric Label; CD: CyDyes (Fluorescence Cyanine Dyes); LC-MS/MS: Liquid chromatography-tandem mass spectrometry; LC-MRM/MS: Multiplexed liquid chromatography multiple-reaction-monitoring mass spectrometry; Nano-RPLC-MS/MS: Nanoscale liquid chromatography coupled to tandem mass spectrometry; ESI-MS/MS: Electrospray ionization mass spectrometry; MALDI-TOF MS: Laser desorption ionization-time of flight mass spectrometry; MS/MS: Tandem mass spectrometry; MRM: Multiple Reaction Monitoring; IHC: Immunohistochemistry; WB: Western Blot; IB: Immunoblotting.