Table 4.

Gene Ontology (GO) enrichment analysis of secreted proteins in pancreatic cancer.

Cellular Component (GO)
Pathway ID	Pathway Description	Gene Count	FDR
GO.0070062	Extracellular exosome	35	1.29 × 1024
GO.0031988	Membrane-bounded vesicle	34	4.57 × 1020
GO.0005615	Extracellular space	25	1.79 × 1019
GO.0044421	Extracellular region part	31	3.35 × 1015
GO.0072562	Blood microparticle	11	1.15 × 1014
GO.0005576	Extracellular region	31	4.02 × 1013
GO.0060205	Cytoplasmic membrane-bounded vesicle lumen	8	4.29 × 1010
GO.0034774	Secretory granule lumen	6	2.35 × 107
GO.0005925	Focal adhesion	9	1.88 × 106
GO.0031093	Platelet alpha granule lumen	5	2.83 × 106
GO.0031091	Platelet alpha granule	5	7.61 × 106
GO.0044433	Cytoplasmic vesicle part	9	2.46 × 105
GO.0005829	Cytosol	19	3.4 × 105
GO.0030141	Secretory granule	7	7.44 × 105
Biological Process (GO)
Pathway ID	Pathway Description	Gene Count	FDR
GO.0006165	Nucleoside diphosphate phosphorylation	9	1.99 × 1011
GO.0006096	Glycolytic process	8	3.4 × 1011
GO.0002576	Platelet degranulation	9	5.25 × 1011
GO.0061621	Canonical glycolysis	7	5.25 × 1011
GO.0019674	NAD metabolic process	8	8.75 × 1011
GO.0046496	Nicotinamide nucleotide metabolic process	8	1.47 × 109
GO.0030168	Platelet activation	10	5.73 × 109
GO.0046364	Monosaccharide biosynthetic process	7	5.73 × 109
GO.0009611	Response to wounding	14	9.81 × 109
GO.0006090	Pyruvate metabolic process	7	1.09 × 108
GO.0042981	Regulation of apoptotic process	17	1.51 × 108
GO.0042060	Wound healing	13	3.84 × 108
GO.0006094	Gluconeogenesis	6	8.46 × 108
GO.0016192	Vesicle-mediated transport	15	1.23 × 107
GO.0006950	Response to stress	23	1.39 × 107
Molecular Function (GO)
Pathway ID	Pathway Description	Gene Count	FDR
GO.0005515	Protein binding	24	0.000171
GO.0019899	Enzyme binding	12	0.00461
GO.0044822	Poly(A) RNA binding	11	0.0069
GO.0003723	RNA binding	12	0.0117
GO.0004634	Phosphopyruvate hydratase activity	2	0.0174

FDR: False discovery rate.