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Regulation of miR-143 and -145 transcription. Schematic representation of the genetic locus containing the microRNAs, with both positive (squared) and negative (rounded) regulators shown to be relevant for their transcription, in both normal and cancer cells. Regulators with direct transcriptional activity are depicted closer to the DNA, and the color code indicates if they regulate both microRNAs as a cluster (fuchsia) miR-143 only (pink), miR-145 only (violet).
