Table 1.

Correlation of EOC hypomethylated blocks with genomic features ^{1, 2.}

Genomic Region	Number of Regions	Size of Regions (bp)	% of Genome	% Regions in Hypo Blocks	Correlation	Jaccard Test P-Value 3,4
EOC Hypomethylated Blocks	2208	8.81E + 08	29	100	N/A	N/A
LADs	1231	1.13E + 09	37	36	Direct	<0.01
Early Replicating	910	7.10E + 08	23	25	Indirect	<0.01
Late-Replicating	1155	5.81E + 08	19	36	Direct	<0.01
CpG islands	27,537	2.10E + 07	1	32	Direct	<0.01
Genes	28,489	1.41E + 09	46	32	Direct	<0.01
	# binding sites	# binding sites in hypo blocks	% binding sites in hypo blocks	Fold Enrichment	Correlation	Projection Test P-value
EZH2 Sites	14,818	6103	41	1.41	Direct	<0.01
SUZ12 Sites	5772	2497	43	1.48	Direct	<0.01
CTCF Sites	162,209	52,216	32	1.10	Direct	<0.01
	# peaks	# peaks in hypo blocks	% peaks in hypo blocks	Fold Enrichment	Correlation	Jaccard Test P-value
H3K4me3	33,116	8655	26	0.90	Indirect	<0.01
H3K9me3	49,328	18,264	37	1.28	Direct	<0.01
H3K27ac	67,989	17,935	26	0.91	Indirect	<0.01
H3K27me3	40,126	15,428	38	1.32	Direct	<0.01
H3K36me3	33,342	6303	19	0.65	Indirect	<0.01
	# of repeats	# repeats in hypo blocks	% repeats in hypo blocks	Fold Change	Correlation	Jaccard Test P-value
LINE-1	951,780	264,352	28	0.96	Direct	<0.01
Alu/SINE	1,194,734	292,495	24	0.84	Indirect	<0.01
Satellites	6775	1052	16	0.64	Indirect	<0.01

1 Hypomethylated blocks were determined from Methyl-seq comparison of NE (OSE + FTE average) to GDHO(+) EOC; 2 Genomic features were retrieved from public databases, as described in Methods; 3 Statistical tests were performed using GenometriCorr (Favorov et al., PLoS Computational Biology, 2012), with hypomethylated block coordinates used as the reference value; 4 All tests, other than CpG islands, gave the same result when using hypomethylated blocks as query and the genomic features as the reference value. In contrast, the association with CpG islands was not significant.