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. 2020 Mar 22;12(3):750. doi: 10.3390/cancers12030750

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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RP4010 and gemcitabine/nab-paclitaxel showed synergistic effects on the inhibition of cell proliferation in vitro. L3.6pl (A), BxPC-3 (B) and MiaPaCa-2 (C) cells were exposed to the indicated concentrations of either RP4010 alone or gemcitabine/nab-paclitaxel, or a combination of RP4010 with gemcitabine/nab-paclitaxel for 72 h, and cell proliferation was evaluated by MTT assay as described in Methods (n = 2). CalcuSyn software was employed to generate isobolograms (shown on the right-hand side panel) and determine CI values from the resulting data.