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. 2020 Mar 20;12(3):736. doi: 10.3390/cancers12030736

Figure 1.

Figure 1

Functions of m6A modification and its writers, erasers and readers in GBM. Abbreviations: RNA-modifying proteins (RMPs): ALKBH5, α-Ketoglutarate-dependent dioxygenase alkB homolog 5; eIF3a/b/h, eukaryotic translation initiation factor 3a/b/h; FTO, Fat mass and obesity-associated protein; Hakai, Cbl proto-oncogene like 1, CBLL1; hnRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1; hnRNPC, heterogeneous nuclear ribonucleoprotein C1/C2; IGF2BP1/2/3, insulin-like growth factor 2 mRNA-binding protein 1/2/3; METTLE3/14, methyltransferase like 3/14; RBM15/15B, RNA-binding motif protein 15/15B; VIRMA, Virilizer like m6A methyltransferase associated protein; WTAP, Wilms’ tumor 1-associated protein; YTHDF1/2/3, YTH N6-methyladenosine RNA binding protein 1/2/3; YTHDC1/2/3, YTH domain-containing 1/2/3; ZC3H13, zinc finger CCCH domain-containing protein 13. Others: A-to-I, adenosine-to-inosine; ADAM19, a disintegrin and metallopeptidase domain 19; ADAR1,adenosine deaminase RNA specific 1; APOBEC3A, apolipoprotein B mRNA editing enzyme catalytic subunit 3A; BCL-X, Bcl-2-like protein 1, BCL2L1; BIN1, bridging integrator 1; c-FLIP, cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein; c-Myc, avian myelocytomatosis viral oncogene homolog; C-to-U, cytidine to uridine; CCND2, cyclin D2; CEBPA, CCAAT enhancer binding protein alpha; COX7B, mitochondrial cytochrome c oxidase subunit 7B; EGFR, epidermal growth factor receptor; EMT, epithelial-to-mesenchymal transition; FOXM1, forkhead box M1; FOXM1-AS, forkhead box M1-antisense RNA; GSCs, glioma stem-like cells; HIF1A-AS2, hypoxia-inducible factor 1 alpha-antisense RNA 2; HMGA1/2, high mobility group AT-hook 1/2; HSP70, heat shock protein 70; IGF2, insulin-like growth factor 2; m6A, N6-methyladenosine; MAPK, mitogen-activated protein kinase; MKI67, marker of proliferation Ki-67; MMP-2, matrix metallopeptidase 2; NCOR2, nuclear receptor corepressor 2; NDUF3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; NDUFS3, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; NDUS7, NADH dehydrogenase iron-sulfur protein 7; OXPHOS, oxidative phosphorylation; PI3K, phosphatidylinositol 3-kinase; PTEN, phosphatase and tensin homolog; QKI-6, Quaking gene isoform 6; RON, macrophage stimulating 1 receptor, MST1R; ROS, reactive oxygen species; RRM2, ribonucleotide reductase regulatory subunit M2; SOX2, SRY-box transcription factor 2; STAT3, signal transducer and activator of transcription 3; TMZ, temozolomide; WWOX, WW domain containing oxidoreductase.