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. 2020 Mar 20;12(3):736. doi: 10.3390/cancers12030736

Figure 2.

Figure 2

Emerging functions of RNA modifications (except m6A) and their writers, erasers and readers in GBM. Abbreviations: Modifications: A-to-I, adenosine-to-inosine; m1A, N1-methyladenosine; m5C, 5-methylcytosine; m6Am, N6, 2′O-dimethyladenosine; hm5C, 5-hydroxymethylcytosine; I, inosine; ψ, pseudouridine. RNA-modifying proteins (RMPs): ADAR1/2/3, adenosine deaminase that acts on RNA 1/2/3; ALYREF, ALY/REF export factor; DCP2, mRNA- decapping enzyme 2; DKC1, dyskerin pseudouridine synthase 1; DNMT2, DNA (cytosine-5-)-methyltransferase 2; METTLE4, methyltransferase like 4; NSUN2/5, NOP2/Sun RNA methyltransferase 2/5; PCIF1, phosphorylated CTD interacting factor 1; PUS1/3/7/10, pseudouridine synthase 1/3/7/10; PUSL1, pseudouridine synthase like 1; PUS7L, pseudouridine synthase 7 like; RPUSD1/2/3/4, RNA pseudouridylate synthase domain-containing 1/2/3/4; TET1/2/3, ten-eleven translocation (TET) family; TRMT6/61A, tRNA methyltransferase 6/61A; TRMT61B, tRNA methyltransferase 61 homolog B; TRMT10C, tRNA methyltransferase 10C, mitochondrial RNase P subunit; TRUB1/2, TruB pseudouridine synthase family member 1/2. Others: c-Myc, avian myelocytomatosis viral oncogene homolog; CDC14B, cell division cycle 14B; NQO1, Quaking gene isoform 6; HIF1A, hypoxia-inducible factor 1 alpha; Mods, modifications; p70S6K, p70 S6 kinase;Skp2, S-phase kinase associated protein 2; PDCD4, programmed cell death 4; Skp2, S-phase kinase associated protein 2.