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Xenograft studies of the Cys-linker-MMAE-based ADC. (A) The tumor volume of the test animals during the treatment and observation period. (B) Changes in the body weights of the mice during the observation period. Nude mice were implanted subcutaneously with NCI-N87 cells. When the tumors reached ~120 mm3, the animals were given vehicle, mil40, or ADC on days 0, 7, 14, and 21. The results are shown as the mean ± SD, n = 6/group.
