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Tolerance study of the Cys-linker-MMAE-based ADC. (A) Body weight changes in male mice after administration of mil40-15. (B) Body weight changes in female mice after administration of mil40-15. (C) Body weight changes in male mice after administration of mil40, mil40-15, and mil40-16. (D) Body weight changes in female mice after administration of mil40, mil40-15, and mil40-16. The results are shown as the mean ± SD, n = 3/group.
