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SAMHD1 modifies antiviral and activity of antimetabolites. Dose response of the nucleoside analogues (A) or anti-folate drugs (B) currently used as anti-cancer treatments in wild-type (■) or SAMHD1-depleted (Δ) MDMs. Inhibition of HIV infection was measured as the percentage of GFP+ cells relative to the no drug condition. Mean ±SD of at least three independent donors performed in duplicate is shown. * p < 0.05; ** p < 0.005; *** p < 0.0005.
