Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 7;24:137. doi: 10.1186/s13054-020-2819-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Schematic representation of the study protocol. Time zero (T₀) was the starting point of septic shock fluid resuscitation and defined as the first time that MAP < 65 mmHg or serum lactate > 2 mmol/l during the ICU stay. According to the different range of initial fluid resuscitation rate (equal to the slope in the graph), the cohort was divided into four groups: group 1 (≥ 0.5 ml/kg/min), group 2 (0.25–0.5 ml/kg/min), group 3 (0.17–0.25 ml/kg/min), and group 4 (< 0.17 ml/kg/min). The “” on the timeline marked ICU admission, shock reversal time (T_r), and ICU and hospital discharge; shock reversal time (T_r), ICU discharge, and hospital discharge must be after T₀ but had no fixed time relationship with T₀. The main variables and measurements of the study are shown in the bottom half of the figure. The period of shock reversal was defined as the duration between T_r and T₀ (abbreviation: ICU = intensive care unit; T₀ = time zero; T₃ = 3 h after T₀; T_r = shock reversal time; VIS = Vasoactive-Inotropic Score; LOS = length of stay)

Inline graphic — Schematic representation of the study protocol. Time zero (T₀) was the starting point of septic shock fluid resuscitation and defined as the first time that MAP < 65 mmHg or serum lactate > 2 mmol/l during the ICU stay. According to the different range of initial fluid resuscitation rate (equal to the slope in the graph), the cohort was divided into four groups: group 1 (≥ 0.5 ml/kg/min), group 2 (0.25–0.5 ml/kg/min), group 3 (0.17–0.25 ml/kg/min), and group 4 (< 0.17 ml/kg/min). The “” on the timeline marked ICU admission, shock reversal time (T_r), and ICU and hospital discharge; shock reversal time (T_r), ICU discharge, and hospital discharge must be after T₀ but had no fixed time relationship with T₀. The main variables and measurements of the study are shown in the bottom half of the figure. The period of shock reversal was defined as the duration between T_r and T₀ (abbreviation: ICU = intensive care unit; T₀ = time zero; T₃ = 3 h after T₀; T_r = shock reversal time; VIS = Vasoactive-Inotropic Score; LOS = length of stay)