Table 1.
Clinical demographics and baseline characteristics by initial fluid resuscitation rate (ml/kg/min)
| Variables | Fluid replacement rate; ml/kg/min | P value | |||
|---|---|---|---|---|---|
| ≥ 0. 5, N = 256 | 0.25–0.49, N = 123 | 0.17–0.24, N = 88 | < 0.17, N = 585 | ||
| Age; year, median (IQR) | 66 (55, 78) | 68 (59, 80) | 70 (53, 79) | 67 (56, 77) | .5† |
| Male sex; N (%) | 126 (49%) | 65 (53%) | 40 (46%) | 296 (51%) | .7‡ |
| White race; N (%) | 242 (95%) | 114 (93%) | 79 (90%) | 526 (90%) | .2‡ |
| Hospital admission weight; kg, median (IQR) | 76 (63, 90) | 81 (64, 100) | 80 (67, 103) | 84 (69, 99) | < .001† |
| Charlson comorbidity index; median (IQR) | 5 (3, 8) | 6 (4, 8) | 6 (3, 8) | 6 (4, 8) | .9† |
| APACHE III score (T0); median (IQR) | 82 (64, 104) | 83 (69, 106) | 86.5 (73, 107) | 86 (70, 103) | .3† |
| SOFA score (T0); median (IQR) | 8 (6, 11) | 9 (7, 12) | 9.0 (6.5, 11.0) | 9 (6, 12) | .4† |
| Infection source | |||||
| Blood | 73 (29%) | 32 (26%) | 25 (28%) | 155 (26%) | .9 |
| Respiratory | 95 (37%) | 38 (31%) | 37 (43%) | 274 (47%) | .002 |
| Abdominal/GI | 44 (17%) | 13 (11%) | 10 (11%) | 78 (13%) | .2 |
| Urinary | 55 (21%) | 28 (23%) | 32 (37%) | 135 (23%) | .02 |
| Soft tissue and bone | 24 (9%) | 11 (9%) | 13 (15%) | 41 (7%) | .08 |
| Other | 23 (9%) | 13 (11%) | 12 (14%) | 54 (9%) | .5 |
| Heart rate (T0), bpm; median (IQR) | 101 (88, 116) | 100 (83, 113) | 105 (88, 117) | 98 (83, 111) | .007 |
| Mean arterial pressure (T0), mmHg; median (IQR) | 64 (57, 73) | 60 (54, 68) | 65 (57, 75) | 66 (59, 76) | < .001 |
| VIS (T0); median (IQR) | 1.6 (0.5, 10.1) | 1.5 (0.6, 12.8) | 1.7 (0.7, 7.2) | 1.7 (0.6, 10.6) | .9 |
Numbers indicate N (%) unless otherwise noted
†Kruskal-Wallis
‡Chi-square