Table 3.
Associations between fluid time and VIS by hour using univariate and multivariable GEE linear regression models
| Variables | Univariate analysis† | Multivariable analysis‡ | ||
|---|---|---|---|---|
| Mean estimate (95% CI) | P value | Mean estimate (95% CI) | P value | |
| Fluid replacement rate; ml/kg/min | < .001 | < .001 | ||
| ≥ 0.5 | 0.00 (ref) | 0.00 (ref) | ||
| 0.25–0.49 | 0.18 (− 1.89, 2.24) | 0.11 (− 1.77, 2.00) | ||
| 0.17–0.24 | − 0.03 (− 2.34, 2.28) | − 0.15 (− 2.23, 1.92) | ||
| < 0.17 | − 2.62 (− 4.08, − 1.16) | − 2.41 (− 3.79, − 1.03) | ||
| VIS time (per 1 h) | 0.20 (0.15, 0.24) | < .001 | 0.18 (0.13, 0.22) | < .001 |
| Age (per year) | − 0.01 (− 0.05, 0.03) | .6 | − 0.03 (− 0.08, 0.02) | .2 |
| Male sex | − 0.07 (− 1.25, 1.11) | .9 | 0.33 (− 0.74, 1.41) | .5 |
| White race | − 0.73 (− 2.79, 1.34) | .5 | − 0.24 (− 2.18, 1.70) | .8 |
| Weight (per 10 kg) | − 0.5 (− 0.7, − 0.4) | < .001 | − 0.5 (− 0.7, − 0.3) | < .001 |
| Charlson comorbidity index | 0.02 (− 0.19, 0.23) | .9 | 0.04 (− 0.18, 0.27) | .7 |
| APACHE III score | 0.09 (0.07, 0.11) | < .001 | 0.05 (0.01, 0.08) | .007 |
| SOFA | 0.68 (0.52, 0.84) | < .001 | 0.41 (0.16, 0.66) | < .001 |
†Mean estimate and P value are adjusted only for the row covariate
‡Mean estimate and P value are adjusted for all covariates listed in the table