. 2020 Apr 7;21:80. doi: 10.1186/s12931-020-01342-y

Table 2.

Characteristics of subjects with methylation data and lung function of IOW cohort, stratified by gender

IOW cohort
	Sub cohort at age 10: Participants with lung function Mean ± SD	Study sample at age 10: Participants with lung function and DNA-M Mean ± SD	P- values	Sub cohort at age 18: Participants with lung function Mean ± SD	Study sample at age 18: Participants with lung function and DNA-M Mean ± SD	P-values
Factors	n = 488	n = 183		n = 395	n = 212
Males
FEV₁(L)	2.05 ± 0.30	2.06 ± 0.29	0.477	4.62 ± 0.62	4.64 ± 0.62	0.621
FVC (L)	2.35 ± 0.34	2.36 ± 0.33	0.813	5.35 ± 0.72	5.35 ± 0.73	0.930
FEV₁/FVC	0.88 ± 0.06	0.88 ± 0.06	0.651	0.87 ± 0.07	0.87 ± 0.07	0.904
Height (cm)	139.00 ± 5.90	138.94 ± 5.95	0.893	177.83 ± 6.65	177.56 ± 6.87	0.568
BMI	17.57 ± 2.52	17.65 ± 2.54	0.665	22.51 ± 3.72	22.64 ± 3.72	0.609
	n(%)	n(%)		n(%)	n(%)
Smoking^a
Non- smoker	–	–	–	222 (56.20)	119 (56.13)	0.813
Current smoker	–	–		93 (23.54)	46 (21.70)
Past smoker	–	–		72 (18.23)	44 (20.75)
Missing	–	–		8 (2.03)	3 (1.42)
Females	n = 492	n = 137		n = 443	n = 241
FEV₁(L)	2.00 ± 0.29	2.01 ± 0.29	0.832	3.51 ± 0.45	3.53 ± 0.43	0.340
FVC (L)	2.23 ± 0.33	2.24 ± 0.34	0.657	4.03 ± 0.53	4.04 ± 0.51	0.737
FEV₁/FVC	0.90 ± 0.06	0.90 ± 0.05	0.337	0.88 ± 0.07	0.87 ± 0.07	0.563
Height (cm)	139.02 ± 6.43	139.22 ± 6.58	0.719	164.68 ± 6.17	165.08 ± 6.37	0.331
BMI	18.74 ± 3.34	18.66 ± 3.41	0.789	23.84 ± 4.72	23.89 ± 4.61	0.870
	n(%)	n(%)		n(%)	n(%)
Smoking^a
Non- smoker	–	–	–	240 (54.18)	129 (53.53)	0.979
Current smoker	–	–		111 (25.06)	61 (25.31)
Past smoker	–	–		87 (19.64)	49 (20.33)
Missing	–	–		5 (1.13)	2 (0.83)

^aActive smoking at age 10 years in the IOW Cohort was not identified