Skip to main content
. 2020 Apr 7;21:80. doi: 10.1186/s12931-020-01342-y

Table 3.

CpGs showing consistent associations in females between the IOW and replication cohorts, ALSPAC and BAMSE

CpG Name Chr. Gene name Location IOW cohort ALSPAC-cohort BAMSE cohort
Coeff. PRaw-value PFDR -value Coeff. P-value Coeff. P-value
cg08095278 1 ASH1L TSS1500 −0.008 0.0031 0.0218 – – −0.031 0.339
cg13342625 1 WDR65 TSS200 −0.009 0.0016 0.0187 – – −0.021 0.663
cg02288301 2 TMEFF2 TSS1500 −0.011 0.0021 0.0201 – – −0.020 0.549
cg08366885 2 RAPH1 5’UTR −0.006 0.0092 0.0381 −0.001 0.889 −0.005 0.758
cg16710348 3 SLC15A2 3’UTR −0.008 0.0114 0.0436 −0.0002 0.975 −0.001 0.980
cg09839318 4 GAK Body −0.007 0.0084 0.0364 −0.002 0.762 −0.035 0.163
cg00930455 7 DLX5 TSS1500 −0.010 0.0055 0.0299 – – −0.0003 0.990
cg04132649 7 TECPR1 Body −0.008 0.0071 0.0345 −0.003 0.573 −0.008 0.770
cg14552568 7 HTR5A Intergenic −0.011 0.0012 0.0187 – – −0.091 0.006
cg15575249 7 INSIG1 Intergenic −0.008 0.0014 0.0187 −0.005 0.523 −0.007 0.826
cg21584493 7 PTPRN2 Body −0.024 0.0033 0.0218 −0.008 0.287 −0.044 0.369
cg09573852 8 IKBKB Body −0.006 0.0054 0.0299 −0.005 0.399 – –
cg23188819 8 FAM160B2 Body −0.007 0.0030 0.0218 −0.009 0.422 – –
cg14319249 9 PTCH1 TSS200 −0.008 0.0021 0.0201 −0.0002 0.987 −0.012 0.684
cg09033333 10 JAKMIP3 Intergenic −0.007 0.0035 0.0223 −0.0002 0.977 – –
cg01082111 11 RPS6KA4 Intergenic −0.016 0.0002 0.0092 −0.005 0.551 −0.058 0.051
cg07427606 12 MMP17 Body −0.007 0.0031 0.0218 – – −0.022 0.412
cg05312779 15 ANPEP 3’UTR −0.010 0.0062 0.0315 – – −0.037 0.220
cg04575609* 16 BANP Body −0.007 0.0021 0.0201 −0.001 0.884 – –
cg04933438 16 WWOX Body −0.012 0.0002 0.0092 – – −0.006 0.849
cg11316510 17 RARA Body −0.006 0.0100 0.0403 −0.012 0.290 – –
cg11493223 17 TMC6 TSS200 −0.008 0.0027 0.0217 −0.005 0.703 −0.039 0.186
cg13206530 18 CELF4 Intergenic −0.011 0.0026 0.0217 −0.0004 0.961 −0.016 0.621
cg00850039 19 ZNF442 TSS200 −0.007 0.0056 0.0299 – – −0.013 0.710
cg10157975 19 ZNF304 TSS1500 −0.006 0.0063 0.0315 −0.020 0.256 −0.003 0.909
cg10027934 22 MAP 3K7IP1 Body −0.014 0.0012 0.0187 – – −0.051 0.081
cg27652464 22 FAM19A5 Body −0.008 0.0022 0.0201 – – −0.028 0.219

Note: 1) Regression coefficients were for the associations of changes in DNA-M with FEV1/FVC changes in females

2) CpGs with the genes’ names in bold font were overlapped across all the three cohorts (IOW-ALSPAC-BAMSE consistent CpGs)

3) In BAMSE cohort, DNA-M of *cg04575609 was excluded at the time of quality control and was not available for the replication analysis

4) Chr. chromosome number, Coeff. coefficients