Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 2;9(3):591. doi: 10.3390/cells9030591

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Proposal of a putative scenario for neuroprotective intervention of PrP^C in AD: 1. Modulating ROS levels; 2. Inhibiting BACE1 activity; 3. Generating PrPN1; 4. Modulating glutamate receptors (both ionotropic (NMDAR) and metabotropic (mGluR5)); 5. Reducing phospho-tau levels through STI-1 interaction and GSK3β inhibition; 6. Reducing ROS levels through STI-1 interaction and consequent SOD modulation; 7. Executing anti-Bax activity; 8. Increasing Zn²⁺ uptake; and 9. Reducing tau levels. Number 10, in italics, represents the direct intervention of ADDLs in PrP^C function, inhibiting its endocytosis and/or homodimerization, and competing with Cu²⁺ binding and homeostasis. TGN: Trans-Golgi Network.