Table 1.

Small molecules targeting HSP70 functional cycle in cancer.

HSP70-Targeting Molecules		Effects	Refs.
SBD-targeting inhibitors	PES (Pifithrin-µ)	Suppressed tumor development in a mouse model of Myc-lymphoma.	[219]
	ADD70	Increased sensitivity of colon cancer and melanoma cells to apoptosis; showed antimetastatic effects in vivo.	[220]
	Acridizinium derivative 1	Induced apoptosis in HeLa cells.	[221]
NBD-targeting inhibitors	Synthetic peptide P17	Decreased melanoma growth in vivo.	[222]
	JG-98 inhibitor (MKT-077 analog)	Decreased tumor growth in MCF7 xenograft model.	[213]
	VER-155008	Inhibited proliferation of human breast and colon cancer cell lines.	[217]
	YK-5	Induced apoptosis and degradation of HSP70/HSP90 client proteins (HER2,Raf-1, Akt kinases) in breast cancer cells.	[223]
	Apoptozole	Induced apoptosis in ovarian, colon and lung cancer cell lines.	[224,225]
HSP70-HSP40 complex inhibitors	MAL3-101	Inhibited proliferation of multiple myeloma cells derived from patients.	[226]
	DMT3132 (MAL3-101 analog)	Reduced proliferation in breast cancer cells.	[227,228]
	Myricetin	Inhibited tumor growth in pancreatic cancer.	[229]
HSP70-NEF complex inhibitors	YM-1	Inhibited tumor growth in mammary and melanoma xenograft models.	[168]
Allosteric HSP70 inhibitors	HS-72	Inhibited growth in HER2-positive breast cancel model.	[230]