Skip to main content
. 2020 Feb 25;9(3):534. doi: 10.3390/cells9030534

Figure 2.

Figure 2

Domain organization of ferlins of bony vertebrates. Ferlin domain organization from selected species (Dr, Danio rerio; Mm, Mus musculus; Hs; Homo sapiens) using the genome browser Ensembl (Release 96 from April 2019) [36] was drawn according to SMART and Pfam [37,38]. The corresponding phylogenetic tree was produced using Clustal Omega multiple sequence alignment program using default parameters [39]. Translated proteins are from e!Ensembl. Zebrafish has 6 ferlin genes; fer1l5 is absent; however, two related otoferlin genes otofa and b are present. In the mouse, all 6 ferlin genes are present and encode proteins, whereas in humans, FER1L4 represents a pseudogene producing long noncoding RNA. Abbreviations: Chr, chromosome.