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. 2020 Mar 5;9(3):629. doi: 10.3390/cells9030629

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Consequences of targeting 80S ribosomes vs. mitoribosomes with respectively eukaryote-specific antibiotics (red arrow) or prokaryote-specific antibiotics (blue arrow). The style of the connecting lines defines the type of function involved: translation by ribosomes (........), transcription (-------), biological effect (^_____). EAA: Essential Amino Acids, LAT1: System L amino-acid transporter 1, RPs: ribosomal proteins, mtRPs: mitochondrial ribosomal proteins, nucDNA: nuclear genome DNA, mtDNA: mitochondrial DNA, rRNA: ribosomal RNA, mt-rRNA: mitochondrial ribosomal RNA, nucDNA-eMP: nuclear DNA-encoded mitochondrial proteins, ETC: electron transport chain.