Figure 8.

(A) Action potential duration at 90% repolarization (APD₉₀) decreased by the end of 30 min. simulated ischemia in the simulated ischemia/reperfusion groups (sI/R) and simulated ischemic preconditioning groups (sIPC) as compared to the normoxia (N) group. (B) Rofecoxib increased the APD₉₀ in adult rat isolated papillary muscles at the end of reperfusion and this effect was reversed by sIPC (*p < 0.05 vs. corresponding normoxia group, #p < 0.05 vs. sI/R + vehicle,†p < 0.05 vs. sI/R + 1 µM rofecoxib, ∆p < 0.05 vs. corresponding sI/R group, n = 5–6).