Skip to main content
. 2020 Mar 6;9(3):640. doi: 10.3390/cells9030640

Figure 1.

Figure 1

Combined exposure to sorafenib and starvation induces cell death in human melanoma cells. (A) Cell death evaluation (percentage of sub-G1 population) of PI-stained BRAFWT (CHL-1 and C8161) and oncogenic BRAFV600E (A375, A2058, SK Mel 05, and SK Mel 28) melanoma cell lines untreated (CTR) or exposed to EBSS (STV), sorafenib (SOR 10 mM) and SOR + STV for 24 h. (Histograms represent mean ± SD, n = 3) * p < 0.0001 compared to control cells; # p < 0.0001 compared to sorafenib-treated cells. One-way ANOVA, Bonferroni post-test. (B) Cell viability was analyzed in CHL-1 and SK Mel 28 cells at 6, 12, and 24 h of STV, SOR, and SOR + STV post treatment. (Histograms represent mean ± SD) * p < 0.0001 compared to control cells. # p < 0.0001 compared to 6h; • p < 0.0001 compared to 6 and 12 h. Two-way ANOVA, Bonferroni post-test.