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Mitochondrial heme routes. Mitochondrial enzyme ferrochelatase (FECH) metallates PP IX, yielding protoheme that is routed to several suborganellar locales, wherein heme b is sequentially modified and/or inserted into the indicated hemoproteins. SDH, succinate dehydrogenase; CcO, cytochrome c oxidase; OMM, outer mitochondrial membrane; IMS, intermembrane space; IMM, inner mitochondrial membrane.
