Table 5.
Description about the list of ongoing clinical trials that are associated with the use of stem cells in curing female reproductive disorders. All of these details were taken from https://stemcellsportal.com/clinical_trials_infertility.
| Pathological Condition | Cell Therapy | Estimated Enrollment | Intervention/ Treatment |
Cliniclatrials.Gov Identifier | Outcome Measures |
|---|---|---|---|---|---|
| Women infertility with thin endometrium or endometrial scarring. | UCMSCs loaded in collagen scaffold | 50 participants | UCMSC-based therapy | NCT03592849 | Evaluation of endometrial thickness, pregnancy rate, living intrauterine fetus, live birth rate, endometrial blood flow, menstrual blood volume and adversities such as infection, allergies, abdominal pain post-operation. |
| Women with POI | AECs | 20 participants | Minimally invasive implantation AECs used with ultrasound guidance | NCT03207412 | Evaluation of serum FSH, primordial egg follicles number, menstrual cycle and menstrual period, LH, AMH and E2, ovarian volume. |
| Repeated IVF failure women with atrophic endometrium | Autologous BMSCs | 46 participants | Transplantation of BMSCs | NCT03166189 | Evaluation of endometrial receptivity, endometrial thickness, pregnancy rate, adversities such as side effects, abdominal discomfort and patient’s tolerance. |
| Women with POF | Autologous BMSCs | 33 participants | Transplantation of BMSCs | NCT02696889 | Evaluation of FSH, AMH, E2 level, menstruation resumption, pregnancy achievement. |
| Women with POF | Autologous AMSCs | 9 participants | Intra-ovarian injection of AMSCs | NCT02603744 | Evaluation of FSH, AMH, antral follicle number and volume, menstruation recurrence rate and pregnancy rate. |
| Women infertility with intrauterine adhesions | UCMSCs loaded in collagen scaffold | 26 participants | UCMSC-based therapy | NCT02313415 | Evaluation of live birth rate, intrauterine adhesion reduction, change of endometrial thickness, menstrual blood volume. |
| Women infertility with intrauterine adhesions and endometrial dysplasia | Autologous BMSCs loaded in collagen scaffold | 30 participants | BMSC-based therapy | NCT02204358 | Evaluation of intrauterine scar reduction, endometrial thickness, menstrual blood volume and pregnancy rate. |
| Women with POF | Autologous BMSCs | 60 participants | Transplantation of BMSCs | NCT02062931 | Evaluation of FSH, AMH, E2 level, hormonal, clinical, ultra sound, menopausal symptoms and pregnancy rate. |
UCMSCs: umbilical cord mesenchymal stem cells; AECs: amniotic epithelial cells; BMSCs: bone marrow-derived mesenchymal stem cells; AMSCs: adipose mesenchymal stem cells; POF: pre-mature ovarian failure; POI: pre-mature ovarian insufficiency; FSH: follicular stimulating hormone; LH: luteinizing hormone; AMH: anti Mullerian hormone; and E2: estradiol.