Table 1.
Reproducibility across different experiments
| Compound | # Repeatsa | t1/2 (mean ± SD)/category (Mouse cytosol)b |
t1/2 (mean ± SD)/category (Human cytosol)b |
|---|---|---|---|
| Buspirone | 17 | >120 min/High | >120 min/High |
| Antipyrine | 17 | >120 min/High | >120 min/High |
| Famciclovir | 17 | 9.5 ± 3.2 min/Low | 10.0 ± 3.1 min/Low |
| Carbazeran | 17 | >120 min/High | 3.5 ± 1.8 min/Low |
at1/2 values of the control compounds across 17 plates were measured by UHPLC/HRMS. t1/2 categories: < 10 min: low; > 30 min: high
bNo SD values provided if all replicate t1/2 values exceeded 120 min