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. 2020 Mar 2;9(3):590. doi: 10.3390/cells9030590

Table 2.

Phenotypical changes within Hepatic Stem/progenitor Cell niche in NAFLD.

NON-ALCOHOLIC
FATTY LIVER		 NON-ALCOHOLIC STEATOHEPATITIS
Hepatic stem/progenitor cells

  • Mostly quiescent

  • Activation

  • Ductular reaction

  • Cytokine release

  • Signaling molecule release
Hepatic stellate cells & portal myofibroblast pool

  • Mostly quiescent

  • Reticular extracellular matrix (ECM) production

  • Initial perisinusoidal fibrosis

  • Activation

  • Fibrillar ECM proteins

  • Progressive fibrosis

  • Signaling molecule release
Liver macrophage pool Lobular macrophages

  • ↑ Lobular macrophages

  • ↓ Lobular M2 macrophages

Portal macrophages

  • No modifications

 Lobular macrophages

  • ↑ M1 lobular macrophages

Portal macrophages

  • ↑ Portal macrophages

  • ↑ M1 portal macrophages

  • ↓ M2 portal macrophages