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. 2020 Mar 4;9(3):613. doi: 10.3390/cells9030613

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Bidirectional transport of estrone-3-sulfate across Caco-2 cell monolayers in the presence or absence of 10 µM SCO-201. Permeability (Papp) values were calculated from steady-state fluxes as described the in the Methods section (Section 2.5). Filled bars show PA-B (apical to basolateral) values, open bars show PB-A (basolateral to apical) values. Values are means ± SD of three individual passages, with three individual permeable supports for each transport direction per passage (n = 3−5, total N = 9). The p-values are indicated in the figure.