Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 4;9(3):613. doi: 10.3390/cells9030613

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

SCO-201 inhibited drug-stimulated ATPase activity of BCRP. (A) The effect of increasing concentrations of SCO-201 on basal and sulfasalazine-stimulated ATPase activity of BCRP. The data are indicated as relative ATPase activity, normalized with respect to basal (untreated) and maximal (sulfasalazine-stimulated) ATPase activity of BCRP. Sulfasalazine alone resulted in a maximal ATPase activity of 104.8 nmol Pi/mg protein/min compared to the baseline activity of 50.68 nmol Pi/mg protein/min. (B,C) The effect of 0.5 µM (B) and 1.5 µM (C) SCO-201 on SN-38-stimulated ATPase activity of BCRP. Error bars on all graphs represent SD determined from duplicates.