Table 3.

Cytochrome P450 (CYP) inhibition.

CYP	Test	Substrate	IC50 (M)
CYP1A	Human hepatocytes	Phenacetin substrate	>1 × 10−4
CYP2B6	Human hepatocytes	Bupropion substrate	NC
CYP2C8	Human liver microsomes	Paclitaxel	>1 × 10−4
CYP2C9	Human liver microsomes	Diclofenac	>1 × 10−4
CYP2C19	Human liver microsomes	Omeprazole	NC
CYP2D6	Human liver microsomes	Dextromethorphan	NC
CYP3A	Human liver microsomes	Midazolam	NC
		Testosterone	>1 × 10−4

NC: not calculable.