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CYP induction.
| CYP | Mean Fold Induction of mRNA at 1× 10−4 M | Mean Fold Enzyme Activity Induction at 1 × 10−4 M | ||||
|---|---|---|---|---|---|---|
| Donor 1 | Donor 2 | Donor 3 | Donor 1 | Donor 2 | Donor 3 | |
| CYP1A | 1 | 0.7 | 0.7 | |||
| CYP1A2 | 0.24 | 0.39 | 0.26 | |||
| CYP2B6 | 0.17 | 0.52 | 0.45 | 0.8 | 0.9 | 0.6 |
| CYP3A | 1.3 | 2.0 | 0.4 | |||
| CYP3A | 0.25 | 0.25 | 0.32 | |||
Fold induction = (activity of test compound treated cells)/(activity of negative control). mRNA fold induction = (mRNA level in test compound treated cells)/(mRNA levels in vehicle treated controls).
