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. 2020 Mar 3;9(3):606. doi: 10.3390/cells9030606

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© 2020 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The role of calcium ions in the regulation of the direction of cell division during embryogenesis. (A) A high concentration of calcium ions negatively regulates functioning of katanin and activate destabilizing properties of MDP25, finally supporting longitudinal alignment of microtubules. (B) Low concentration of calcium ions has limited impact on katanin or MDP25. In this situation katanin activity is maintained and function of MDP25 is stopped, which results in transverse alignment of microtubules.