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. 2020 Mar 13;9(3):704. doi: 10.3390/cells9030704

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CA III inhibits the promoter activity of E-cadherin and promotes EMT-related transcription factors Slug and Twist in oral cancer cells. (A) The E-cadherin promoter activity of SCC-9 and SAS CA III stable cells. The values of luciferase activity were normalized by β-galactosidase expression. * p < 0.05 compared with the GFP. (B) The mRNA levels of EMT-related transcription factors Slug and Twist were analyzed by real-time PCR. The relative mRNA expression was normalized to GAPDH. * p < 0.05 compared with the GFP. (C) The protein expression of EMT-related transcription factors Slug and Twist was analyzed by Western blot. β-actin was used as the loading control. (D) The protein expression of EMT-related transcription factors Slug and Twist after transfection with scrambled siRNA or CA III siRNA in CA III stable cells. β-actin was used as the loading control. (E) Correlation between CA III and CDH1 mRNA expression in the oral cancer tissue from the GEO database. (F) Correlation between CA III and VIM mRNA expression in the oral cancer tissue from the GEO database.