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Genomic and epigenomic heterogeneity in cancer. (A) Upon (micro)environmental insults (low oxygen, nutrient depletion, anti-cancer drugs), genomic and epigenomic heterogeneity in cancer cell population facilitate the survival and outgrowth of the clones with the features crucial for the adaptation to changing conditions (purple circles). (B) The examples of genetic and alterations that affect each other during cancer microevolution.
