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. 2020 Mar 16;9(3):727. doi: 10.3390/cells9030727

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Neurotransmitters acting through protein kinases and phosphatases regulate glycogen synthase kinase 3β (GSK3β) activity. GSK3β influences the strength of excitatory and inhibitory synapses. Green arrows represent activation, red arrows represent inhibition, black arrows represent translocation. Abbreviations: NMDAR: N-methyl-d-aspartate receptor, AMPAR: α-amino-3-hydroxy-5-methyl-4-izoxazole propionic acid receptor, GABA_BR: γ-aminobutyric acid receptor type B, D_1/2/3R: dopamine receptors, 5-HT_1/2A/7R: serotonin receptors, α_1A/α₂/βAR: adrenergic receptors, PKA: protein kinase A, AKT: protein kinase B, PKC: protein kinase C, PP2A/2B: protein phosphatases 2A/2B, CaMK2: calcium/calmodulin dependent protein kinase 2, GSK3β: glycogen synthase kinase 3β.