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. 2020 Mar 16;9(3):727. doi: 10.3390/cells9030727

Figure 2.

Figure 2

GSK3β is a part of neurotrophic and pro-inflammatory factors signaling pathways. Green arrows represent activation, red arrows represent inhibition. Green-red arrow denotes a dual, dependent on the physiological state of a cell, action of GSK3β. Abbreviations: WNT: Wingless-related integration site, LRP5/6: low-density lipoprotein receptor-related protein 5 and 6, DSH: Disheveled, 5-HT1BR—serotonin 1B receptor, ERK: extracellular signal-regulated kinase, APC: adenomatous polyposis coli, BDNF: brain-derived neurotrophic factor, TrkB: tropomyosin receptor kinase B, PI3K: phosphoinositide 3-kinase, AKT: protein kinase B, IL-1β: interleukin 1β, IL-1R: interleukin 1β receptor, TNFα: tumor necrosis factor α, TNFR: tumor necrosis factor α receptor, IKK: IκB kinase, IκBα: nuclear factor of light polypeptide gene enhancer in B-cells inhibitor α, NF-κB: Nuclear factor κ-light-chain-enhancer of activated B cells, mTOR: mammalian target of rapamycin, REDD1: regulated in development and DNA damage response-1, DNMT3a: DNA methyltransferase 3a, GSK3β: glycogen synthase kinase 3β.