Table 1.
Current clinical trials testing the therapeutic potential of exosomes from several sources in different human diseases.
| Exosomes Type | Condition to Be Treated | Locations | Reference |
|---|---|---|---|
| CAP-1002 (Cardiosphere-Derived Cells: CDCs) | Duchenne muscular dystrophy | Multicenter American Study (California, Florida, Missouri, Ohio, Utah, Wisconsin) | [121] |
| Curcumin conjugated with plant exosomes | Colon cancer | University of Louisville, USA | [122] |
| Ginger and aloe plants exosomes | Polycystic ovary syndrome | University of Louisville Louisville, Kentucky, USA |
[123] |
| DEX | Cancer vaccination to lung cancer | Gustave Roussy, Cancer Campus, Grand Paris | [124] |
| MSC-derived exosomes with KrasG12D siRNA (“iExosomes”) | Pancreatic cancer | M.D. Anderson Cancer Center, USA | [125] |
| MSCExo | Healing of large and refractory macular holes | Tianjin Medical University Eye Hospital (China) | [126] |
| MSC derived microvesicles and exosomes | Type I Diabetes Mellitus | General Committee of Teaching Hospitals and Institutes, Egypt | [127] |
| Umbilical mesenchymal stem cells derived exosomes | Dry eye symptoms in patients with chronic Graft Versus Host Diseases (cGVHD) | Zhongshan Ophthalmic Center, Sun Yat-sen University, China. | [128] |
| Exosomes derived from amniotic liquid stem cell | Depression, anxiety and dementia | Neurological Associates of West Los Angeles, USA | [129] |
| Exosome produced from neonatal stem cell | Craniofacial neuralgia | Neurological Associates of West Los Angeles, USA | [130] |
| MSCExo enriched by miR-124 | Disability of patients with acute ischemic stroke | Isfahan University of Medical Sciences, Iran | [131] |
| Stem cell conditioned medium | Chronic ulcer wounds [12] | Stem Cell and Cancer Institute, Kalbe Farma TbkPT Pharma Metric Labs, Indonesia. | [132] |
| Human MSC-exosomes | Bronchopulmonary dysplasia | United Therapeutics USA. | [119] |