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. 2020 Mar 12;9(3):697. doi: 10.3390/cells9030697

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A cartoon representation of phospholipase beta (PLCβ) signaling. PLCβ hydrolyzes membrane-bound PtdIns(4,5)P2 to inositol 1,4,5-trisphophate (IP3) and diacylglycerol (DAG), which are important second messengers in the downstream signaling pathway, regulating Ca²⁺ mobilization and protein kinase C (PKC) activation.