Table 1.

Subcompartmental localization of nuclear PIs and their metabolic enzymes.

Phosphoinositides	Nuclear Localization
PtdIns(3,4,5)P3	Matrix [39], nucleoplasm [40], speckles [41], Nucleoli [40]
PtdIns(4,5)P2	Speckles, nucleoli [42], nucleoplasm [38], nuclear lipid islets [43]
PtdIns (3,4)P2	Speckles [41], nuclear membrane [44]
PtdIns5P	Chromatin and matrix [45]
PtdIns4P	Nucleoli [38], speckles [38], chromatin [35]
PtdIns3P	Nucleoli [35] matrix [46]
PI Dependent Metabolizing Enzymes
Nuclear Phospholipases
PLCβ1	Speckles [6], matrix [5]
PLCδ1	Matrix [47]
PLCδ4	Nucleus [7]
PLCε	Perinuclear space [48]
Nuclear Phosphatases
PTEN	Nucleoli [49], chromatin [50]
INPP5K/SKIP	Speckles [51]
SHIP1	Nucleoli [52]
SHIP2	Speckles [41]
Type I PtdIns(4,5)P2 4-phosphatase	Nucleus [53]
Nuclear Kinases
DGKθ	Speckles [54]
DGK isoforms: α, ζ	Matrix [55,56]
PKC isoforms: α, βII, δ, η	Nucleus [57,58]
IPMK	Nucleus [59]
PIPKIα	Speckles [60], nucleoplasm [60], matrix [61]
PIPKIγ_i4	Speckles [62], matrix [61]
PIPKIIα	Speckles [63], matrix [61]
PIPKIIβ	Speckles [63], matrix [61]
PI3K p110β	Nucleus [64]
PI3K IIα	Speckles [65]
PI3K IIβ	Matrix [46,66]
PI4KIIα	Nucleus [67]
PI4KIIβ	Speckles [68]
PI4KIIIα	Nucleoplasm and Nucleoli [67]
PI4KIIIβ	Nuclear pore [49]

Abbreviations: PtdIns, phosphatidylinositol; PLC, phospholipase C; PTEN, phosphatase and tensin homolog deleted on chromosome 10; INPP5K, inositol polyphosphate 5 phosphatase K; SKIP, skeletal muscle and kidney enriched inositol phosphatase; SHIP, src homology 2 (SH2) domain containing inositol phosphatase; DGK, diacylglycerol kinase; PKC, protein kinase C, IPMK, inositol polyphosphate multikinase; PIPK, phosphatidylinositol phosphate kinase; PI3K, phosphatidylinositol-3-kinase; PI4K, phosphatidylinositol 4-kinase.