Figure 1.

Distinguishing features of acute and chronic cellular senescence. Acute cellular senescence, depicted on the left side of Figure 1, involves coordinated recognition of senescent cells by immune cells, leading to their rapid elimination and replacement by healthy cells. Chronic cellular senescence, depicted on the right side of Figure 1, involves the accumulation of dysfunctional senescent cells, with local and systemic manifestation of the senescence associated secretory phenotype (SASP). Chronic inflammation linked to the accumulation of senescent cells with the SASP promotes further cellular senescence and age-associated pathology. (Created with BioRender).