Figure 7.

Effects of silibinin treatment on TXNIP, MAPK, and AP-1 expressions in the lung tissue from SiONPs-exposed mice. Protein expression was evaluated by Western blotting analysis, and densitometric value of protein expression was determined by Chemi-Doc. NC, normal control mice treated with PBS only; SiONPs, mice treated with SiONPs intranasal instillation; DEX, mice treated with dexamethasone (2 mg/kg) + SiONPs intranasal instillation; Sili 20 and 40, mice treated with silibinin (20 and 40 mg/kg, respectively) + SiONPs intranasal instillation. Data are represented as means ± SD (n = 6). ^## p < 0.01 vs. NC group, ^*,^** p < 0.05 and < 0.01 vs. SiONPs group, respectively.