Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 8;9(3):656. doi: 10.3390/cells9030656

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Progerin expression restricted to VSMCs impairs aortic contraction, but VSMC-specific and EC-specific progerin expression is not sufficient to cause defective vessel relaxation. Wire myography was performed in thoracic aorta rings from 14-week-old mice expressing progerin specifically in VSMCs (Lmna^LCS^/LCSSM22α^tg^/+) or in ECs (Lmna^LCS^/LCSTie2^tg^/+) and in control mice without progerin expression (Lmna^LCS^/LCS). (A) Contraction induced by phenylephrine (left) and KCl (right) in aortic rings from Lmna^LCS^/LCSSM22α^tg^/+ mice and Lmna^LCS^/LCS controls. (B) Endothelium-dependent vasodilation induced by acetylcholine (left) and endothelium-independent vasodilation induced by diethylamine NONOate (DEA-NO) (right) in aortic rings from Lmna^LCS^/LCSSM22α^tg^/+ mice and Lmna^LCS^/LCS controls. (C) Contraction induced by phenylephrine (left) and KCl (right) in aortic rings from Lmna^LCS^/LCSTie2^tg^/+ mice and Lmna^LCS^/LCS controls. (D) Endothelium-dependent vasodilation induced by acetylcholine (left) and endothelium-independent vasodilation induced by DEA-NO (right) in aortic rings from Lmna^LCS^/LCSTie2^tg^/+ mice and Lmna^LCS^/LCS controls. Statistical differences were analyzed by two-way ANOVA with Bonferroni’s post-hoc test for acethylcholine, DEA-NO, and phenylephrine data, and by two-tailed t-test for KCl data. * p < 0.05; *** p < 0.001.