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. 2020 Mar 8;9(3):656. doi: 10.3390/cells9030656

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sodium nitrite treatment improves vascular tone regulation in progeroid mice. Wire myography in thoracic aorta rings from 14-week-old Lmna^G609G^/G609G and wild-type mice (Lmna^+/+) treated with sodium nitrite in drinking water for 6 weeks. (A) Endothelium-dependent vasodilation induced by acetylcholine. (B) Endothelium-independent vasodilation induced by diethylamine NONOate (DEA-NO). (C) Contraction induced by phenylephrine. (D) Contraction induced by KCl. Statistical differences were analyzed by two-way ANOVA with Bonferroni’s post-hoc test for acetylcholine, DEA-NO and phenylephrine data, and by two-tailed t-test for KCl data. * p < 0.05.