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. 2020 Mar 11;9(3):684. doi: 10.3390/cells9030684

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proteoglycan 4 (PRG4) is overexpressed in the thickened and calcified regions of the aortic valve and associates with calcification related genes: (A) Proteoglycan 4 (PRG4) expression from N = 64 patients in healthy, thickened, and calcified regions of the same valve. (B–F) PRG4 mRNA association in healthy regions (Spearman correlation coefficient; N = 64) with (B) bone morphogenetic protein 2 (BMP2), (C) dentin matrix acidic phosphoprotein 1 (DMP1), (D) runt-related transcription factor 2 (RUNX2), (E) integrin binding sialoprotein (IBSP), and (F) interleukin 6 (IL6). Statistical significance was determined using a 1-way ANOVA repeated measurements followed by a Tukey post hoc multiple comparisons analysis; ** p < 0.01.