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Effects of recombinant human proteoglycan 4 (rhPRG4) on mRNA levels of (A) bone morphogenetic protein 2 (BMP2), (B) runt-related transcription factor 2 (RUNX2), and (C) SRY-Box transcription factor 9 (SOX9) gene expression after 24-h and 9-day culture (N = 3–4): Statistical significance was determined using a 2-way ANOVA repeated measurements followed by a Holm–Sidak post hoc multiple comparisons analysis; * p < 0.05, ** p < 0.01, and *** p < 0.001.
