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. 2020 Mar 15;9(3):722. doi: 10.3390/cells9030722

Figure 6.

Figure 6

ODZ10117 reduces tumor growth and increases survival in glioblastoma xenograft models. (A,B) Glioblastoma orthotopic xenograft model was established by injecting GSC528 cells into the right striatum of 6-week-old BALB/c nu/nu nude mice. Kaplan-Meier survival curves of tumor-bearing mice treated with vehicle alone or ODZ10117 (0.1 or 1 mg/kg, n = 6) (A). H&E and IHC staining of mouse tumor tissues were performed on day 77 after transplantation (B). Scale bar: 200 (IHC) or 500 μm (H&E). (C,D) Subcutaneous tumor xenograft model was established by injecting U87-MG cells suspended in 25% Matrigel in PBS into the flank of BALB/c nude mice (n = 6). The mice were treated with vehicle (0.1% DMSO) alone or ODZ1017 (40 μM) at 2-day intervals for 2 weeks. Tumor growth was measured every other day (C) and tumor sections were subjected to H&E and IHC staining (D). ** p < 0.005. Scale bar: 100 μm.