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. 2020 Mar 16;9(3):730. doi: 10.3390/cells9030730

Table 2.

Correlation of the adipose IRF5 gene expression with various markers.

Marker Type Diabetic Lean/Overweight Diabetic Obese
Clinical/metabolic markers

  • BMI: r = 0.62, p = 0.04*

  • PBF: r = 0.60, p = 0.05*

  • Insulin: r = 0.76, p = 0.05*

  • HOMA-IR: r = 0.77, p = 0.006**

  • CRP: r = 0.95, p = 0.004**

  • HbA1c: r = 0.01, p = 0.98

  • FBG: r = 0.14, p = 0.65

  • Cholesterol: r = 0.02, p = 0.96

  • HDL: r = 0.21, p = 0.48

  • LDL: r = 0.001, p = 0.99

  • Triglycerides: r = 0.27, p = 0.38

  • BMI: r = 0.10, p = 0.64

  • PBF: r = 0.07, p = 0.74

  • Insulin: r = 0.09, p = 0.67

  • HOMA-IR: r = 0.10, p = 0.65

  • CRP: r = 0.20, p = 0.32

  • HbA1c: r = 0.04, p = 0.81

  • FBG: r = 0.05, p = 0.79

  • Cholesterol: r = 0.25, p = 0.14

  • HDL: r = 0.10, p = 0.65

  • LDL: r = 0.25, p = 0.17

  • Triglycerides: r = 0.12, p = 0.49
Inflammatory cytokines/chemokines or chemokine receptors

  • TNF-α: r = 0.02, p = 0.96

  • IL-1β: r = 0.14, p = 0.66

  • IL-5: r = -0.60, p = 0.05*

  • IL-6: r = 0.19, p = 0.54

  • IL-18: r = 0.01, p = 0.97

  • IL-23A: r = 0.10, p = 0.79

  • CXCL8: r = 0.10, p = 0.74

  • CXCL9: r = 0.06, p = 0.84

  • CXCL10: r = 0.14, p = 0.65

  • CCL2: r = 0.01, p = 0.98

  • CCL5: r = 0.10, p = 0.79

  • CCL7: r = 0.10, p = 0.75

  • CCL11: r = 0.07, p = 0.80

  • CCL19: r = 0.30, p = 0.32

  • CCR1: r = 0.14, p = 0.62

  • CCR2: r = 0.52, p = 0.06

  • CCR5: r = 0.34, p = 0.26

  • TNF-α: r = 0.40, p = 0.02*

  • IL-1β: r = 0.18, p = 0.39

  • IL-5: r = −0.10, p = 0.71

  • IL-6: r = 0.10, p = 0.67

  • IL-18: r = 0.44, p = 0.01*

  • IL-23A: r = 0.44, p = 0.008**

  • CXCL8: r = 0.41, p = 0.02*

  • CXCL9: r = 0.01, p = 0.95

  • CXCL10: r = 0.07, p = 0.70

  • CCL2: r = 0.50, p = 0.004**

  • CCL5: r = 0.28, p = 0.14

  • CCL7: r = 0.40, p = 0.02*

  • CCL11: r = 0.22, p = 0.21

  • CCL19: r = 0.12, p = 0.49

  • CCR1: r = 0.51, p = 0.002**

  • CCR2: r = 0.10, p = 0.75

  • CCR5: r = 0.75, p < 0.0001****
Monocyte/macrophage markers

  • CD11c: r = 0.06, p = 0.85

  • CD68: r = 0.10, p = 0.74

  • CD86: r = 0.27, p = 0.36

  • CD163: r = 0.64, p = 0.01*

  • CD302: r = –0.45, p = 0.10

  • CD11c: r = 0.38, p = 0.02*

  • CD68: r = 0.63, p < 0.0001****

  • CD86: r = 0.61, p = 0.0002***

  • CD163: r = 0.67, p < 0.0001****

  • CD302: r = 0.30, p = 0.08
TLR/non-TLR innate immune markers

  • TLR2: r = 0.59, p = 0.03*

  • TLR3: r = 0.12, p = 0.69

  • TLR4: r = 0.08, p = 0.79

  • TLR7: r = 0.43, p = 0.13

  • TLR8: r = 0.60, p = 0.04*

  • TLR9: r = 0.32, p = 0.27

  • TLR10: r = 0.03, p = 0.91

  • Dectin-1: r = 0.10, p = 0.79

  • IL-1RL1: r = 0.64, p = 0.02*

  • FGL-2: r = 0.14, p = 0.63

  • TLR2: r = 0.78, p < 0.0001****

  • TLR3: r = 0.27, p = 0.15

  • TLR4: r = 0.70, p < 0.0001****

  • TLR7: r = 0.50, p = 0.003**

  • TLR8: r = 0.73, p < 0.0001****

  • TLR9: r = 0.22, p = 0.21

  • TLR10: r = 0.45, p = 0.008**

  • Dectin-1: r = 0.62, p < 0.0001****

  • IL-1RL1: r = 0.22, p = 0.21

  • FGL-2: r = 0.40, p = 0.02*
TLR-associated signaling molecules and transcription factors

  • MyD88: r = 0.35, p = 0.24

  • NF-κB: r = 0.02, p = 0.95

  • IRF3: r = 0.26, p = 0.39

  • IRF4: r = 0.92, p < 0.0001****

  • AML1: r = 0.45, p = 0.10

  • MyD88: r = 0.64, p < 0.0001****

  • NF-κB: r = 0.50, p = 0.003**

  • IRF3: r = 0.40, p = 0.04*

  • IRF4: r = 0.36, p = 0.05*

  • AML1: r = 0.34, p = 0.05*

Note: Number of asterisks corresponds to the statistical significance level.