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. 2020 Mar 14;9(3):721. doi: 10.3390/cells9030721

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differential transcriptomic profile of urine EVs and diagnostic capacity. Volcano plot (−log₁₀(p-value) and log₂(fold-change); up left), heatmap of the differentially expressed transcripts (up right) and diagrams with the diagnostic capacity with the highest AUC values of the 10 selected mRNAs and 5 selected non-coding RNAs in serum EVs from (A) CCA vs. Healthy individuals; (B) CCA vs. PSC; (C) CCA vs. (PSC + UC + Healthy individuals). Abbreviations: AI, accuracy index; AUC, area under the receiver operating characteristic curve; CI, confidence interval; miRNA, microRNA; lncRNA, long non-coding RNA; miscRNA, miscellaneous RNA; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value; SEN, sensitivity; snRNA, small nuclear RNA; snoRNA, small nucleolar RNA; SPE, specificity; vtRNA, vault RNA.

Differential transcriptomic profile of urine EVs and diagnostic capacity. Volcano plot (−log₁₀(p-value) and log₂(fold-change); up left), heatmap of the differentially expressed transcripts (up right) and diagrams with the diagnostic capacity with the highest AUC values of the 10 selected mRNAs and 5 selected non-coding RNAs in serum EVs from (A) CCA vs. Healthy individuals; (B) CCA vs. PSC; (C) CCA vs. (PSC + UC + Healthy individuals). Abbreviations: AI, accuracy index; AUC, area under the receiver operating characteristic curve; CI, confidence interval; miRNA, microRNA; lncRNA, long non-coding RNA; miscRNA, miscellaneous RNA; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value; SEN, sensitivity; snRNA, small nuclear RNA; snoRNA, small nucleolar RNA; SPE, specificity; vtRNA, vault RNA.