Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
TF isoforms acting as DNs (blue DN) can preserve DNA binding to target genes but do not have transactivation or repressive potential because of (a) the loss of the TAD or repressive domain (RD) by AS or (b) impaired recruitment of transcriptional co-regulators (green CoR) necessary for proper transcriptional regulation.
