Table 2.
Transcription factors (TFs) and respective splice variants with oncogenic properties characterized by different activating/repressing ability on the same target genes physiologically regulated by isoforms expressed in normal cells. Tumor-promoting (TP) splice variants with clinical correlation data and relative AS domains have been listed. DBD (DNA binding domain), TAD (transactivation domain), Y (pyrimidine), R (purine).
| TF | DNA Binding Motif | Physiological Regulated Processes | Splice Variants | TP Splice Variants | AS Domains in TP Splice Variants | Ref. |
|---|---|---|---|---|---|---|
| MEF2C | YTA(A/T)4TAR | Muscle cell proliferation and differentiation | Mef2Cα1 Mef2Cα2 |
Mef2Cα1 | Adjacent to DBD | [65] |
| MITF | TCATGTGCT | Melanocyte proliferation and differentiation | (+) MITF (−) MITF |
(−) MITF | Adjacent to DBD | [68,69,70,71,72,73] |
| NFAT2 | (A/T)GGAAA | Cell proliferation and differentiation, apoptosis, inflammatory response | NFAT2α NFAT2β |
NFAT2α | TAD | [78,82] |