Table 3.
Attribute | Level | Patients (n = 137) | Rheumatologists (n = 90) | ||||
---|---|---|---|---|---|---|---|
Partial utility | SE | p value* | Partial utility | SE | p value* | ||
Time with optimal QoL | 1 year | 0.244 | 0.036 | < 0.001 | 0.195 | 0.045 | < 0.001 |
10 years | 2.44 | 1.951 | |||||
7 years | 1.708 | 1.366 | |||||
5 years | 1.22 | 0.976 | |||||
2 years | 0.488 | 0.39 | |||||
Substantial improvement of RA symptoms | 1% patientsa | 0.003 | 0.003 | 0.251 | 0.015 | 0.004 | < 0.001 |
9 out of 10 patients (90%) | 0.303 | 1.35 | |||||
7 out of 10 patients (70%) | 0.235 | 1.023 | |||||
5 out of 10 patients (50%) | 0.168 | 0.731 | |||||
3 out of 10 patients (30%) | 0.101 | 0.438 | |||||
Onset of treatment action | 7 days (ref) | 0.000 | – | – | 0.000 | – | – |
15 days | − 0.372 | 0.285 | 0.193 | − 0.602 | 0.356 | 0.091 | |
1 month | − 0.562 | 0.255 | 0.027 | − 1.083 | 0.326 | 0.001 | |
3 months | 0.194 | 0.275 | 0.481 | − 0.715 | 0.342 | 0.036 | |
Severe adverse events | 1% patientsa | − 0.156 | 0.058 | 0.007 | − 0.182 | 0.074 | 0.014 |
1 out of 100 patients (1%) | − 0.156 | − 0.182 | |||||
5 out of 100 patients (5%) | − 0.781 | − 0.908 | |||||
Mild adverse events | 1% patientsa | 0.003 | 0.014 | 0.856 | − 0.014 | 0.018 | 0.444 |
10 out of 100 patients (10%) | 0.025 | − 0.139 | |||||
30 out of 100 patients (30%) | 0.076 | – 0.416 | |||||
Mode of administration | Daily Oral (ref) | 0.000 | – | – | 0.000 | – | – |
Weekly subcutaneous | − 1.394 | 0.372 | < 0.001 | − 1.683 | 0.461 | < 0.001 | |
Monthly subcutaneous | − 0.375 | 0.364 | 0.302 | − 0.249 | 0.442 | 0.574 | |
Monthly intravenous | − 0.956 | 0.366 | 0.009 | – 0.446 | 0.458 | 0.331 | |
Additional cost/month for treatment | Additional 1€/month | − 0.012 | 0.007 | 0.102 | – 0.009 | 0.009 | 0.296 |
0 | 0 | 0 | |||||
10 | − 0.119 | – 0.092 | |||||
20 | − 0.238 | − 0.185 | |||||
50 | − 0.594 | − 0.462 |
Bold values indicate that there is statistical significance (p < 0.05)
QoL quality of life, RA rheumatoid arthritis, SE standard error
aRefers to a 1% of increase of the proportion of patients