Splitting the first infusion of intravenous daratumumab over 2 days is an approved alternative dosing regimen to reduce the duration of the first infusion and provide flexibility for patients and healthcare providers, without increasing the rate of infusion-related reactions.

Pharmacokinetics (PK) data from the MMY1001 study and the population PK simulation demonstrate that daratumumab concentration profiles were comparable following completion of administration of the first 16-mg/kg dose of daratumumab regardless of whether it was administered as a split first dose or a single first dose.

These findings support the use of an alternative split first dose regimen of intravenous daratumumab for the treatment of multiple myeloma.